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2015 ; 282
(22
): 4279-88
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Recent insights into cell death and autophagy
#MMPMID26367268
Fitzwalter BE
; Thorburn A
FEBS J
2015[Nov]; 282
(22
): 4279-88
PMID26367268
show ga
Macroautophagy (hereafter autophagy) is an evolutionarily-ancient mechanism by
which cellular material is delivered to lysosomes for degradation. Autophagy and
cell death are intimately linked. For example, both processes often use the same
molecular machinery and recent work suggests that autophagy has great influence
over a cell's decision to live or die. However, this decision-making is
complicated by the fact that the role of autophagy in determining whether a cell
should live or die goes both ways: autophagy inhibition can result in more or
less cell death depending on the death stimulus, cell type or context. Autophagy
may also differentially affect different types of cell death. In the present
review, we discuss the recent literature that helps make sense of this apparently
inconsistent role of autophagy in influencing a cell to live or die.
|Animals
[MESH]
|Apoptosis/*physiology
[MESH]
|Autophagy/*physiology
[MESH]
|Humans
[MESH]
|Necrosis
[MESH]
|Receptor-Interacting Protein Serine-Threonine Kinases/physiology
[MESH]
|Receptors, Tumor Necrosis Factor, Type I/physiology
[MESH]