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2017 ; 6
(ä): 304
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Recent advances in understanding spondyloarthritis
#MMPMID28413624
Gaston JSH
F1000Res
2017[]; 6
(ä): 304
PMID28413624
show ga
This review is concerned with a number of recent publications that contribute to
current thinking on the pathogenesis of spondyloarthritis. The areas covered
include the lymphocyte population in the enthesis, which is thought to drive
enthesitis, and hence clinical manifestations. The debate on how HLA-B27 is
implicated in inflammation is also considered, together with recent and
contradictory evidence on the effects of the peptide-trimming enzyme ERAP1 on B27
expression and hence susceptibility to spondylitis. Lastly, a recent report on
the role of the gut microbiome in an important model of spondyloarthritis is
considered.