Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26937272
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 F1000Res
2015 ; 4
(ä): ä Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Recent advances in understanding of chronic kidney disease
#MMPMID26937272
Yamaguchi J
; Tanaka T
; Nangaku M
F1000Res
2015[]; 4
(ä): ä PMID26937272
show ga
Chronic kidney disease (CKD) is defined as any condition that causes reduced
kidney function over a period of time. Fibrosis, tubular atrophy and interstitial
inflammation are the hallmark of pathological features in CKD. Regardless of
initial insult, CKD has some common pathways leading CKD to end-stage kidney
disease, including hypoxia in the tubulointerstitium and proteinuria. Recent
advances in genome editing technologies and stem cell research give great
insights to understand the pathogenesis of CKD, including identifications of the
origins of renal myofibroblasts and tubular epithelial cells upon injury.
Environmental factors such as hypoxia, oxidative stress, and epigenetic factors
in relation to CKD are also discussed.