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F1000Res
2016 ; 5
(?): ? Nephropedia Template TP
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Recent advances in understanding and treating vasculitis
#MMPMID27347395
Koster MJ
; Warrington KJ
F1000Res
2016[]; 5
(?): ? PMID27347395
show ga
Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitides (AAVs) are
near universally fatal conditions if untreated. Although effective therapeutic
options are available for these diseases, treatment regimens are associated with
both short- and long-term adverse effects. The recent identification of effective
B-cell-targeted therapy with an anti-CD20 monoclonal antibody has transformed the
treatment landscape of AAV. Questions, nevertheless, remain regarding the
appropriate timing, dose, frequency, duration, and long-term effects of
treatment. The aim of this article is to provide an overview of the current
information, recent advances, ongoing clinical trials, and future treatment
possibilities in AAV.