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2015 ; 7
(ä): 55
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Recent advances in understanding and managing leiomyosarcomas
#MMPMID26097728
Duffaud F
; Ray-Coquard I
; Salas S
; Pautier P
F1000Prime Rep
2015[]; 7
(ä): 55
PMID26097728
show ga
Leiomyosarcomas are malignant mesenchymal tumours that derive from the smooth
muscle lineage. They are studied and frequently treated as if they are the same
as other soft tissue sarcomas. Recent developments suggest that a different
approach may be more appropriate. Their underlying genetic mechanisms remain
unclear, and complex. Unbalanced karyotypic defects are the only shared features
observed across different leiomyosarcoma subtypes. Unlike other soft tissue
sarcomas, leiomyosarcomas are particularly sensitive to the combination of
gemcitabine and docetaxel. Furthermore, treatment with trabectedin has shown a
good efficacy in leiomyosarcomas, mainly in the form of chronic disease
stabilisation.