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2017 ; 6
(ä): 386
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Recent advances in understanding Epstein-Barr virus
#MMPMID28408983
Stanfield BA
; Luftig MA
F1000Res
2017[]; 6
(ä): 386
PMID28408983
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Epstein-Barr virus (EBV) is a common human herpes virus known to infect the
majority of the world population. Infection with EBV is often asymptomatic but
can manifest in a range of pathologies from infectious mononucleosis to severe
cancers of epithelial and lymphocytic origin. Indeed, in the past decade, EBV has
been linked to nearly 10% of all gastric cancers. Furthermore, recent advances in
high-throughput next-generation sequencing and the development of humanized mice,
which effectively model EBV pathogenesis, have led to a wealth of knowledge
pertaining to strain variation and host-pathogen interaction. This review
highlights some recent advances in our understanding of EBV biology, focusing on
new findings on the early events of infection, the role EBV plays in gastric
cancer, new strain variation, and humanized mouse models of EBV infection.