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2013 ; 3
(1
): 198-225
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Recent advances in cellular glycomic analyses
#MMPMID24970165
Furukawa J
; Fujitani N
; Shinohara Y
Biomolecules
2013[Feb]; 3
(1
): 198-225
PMID24970165
show ga
A large variety of glycans is intricately located on the cell surface, and the
overall profile (the glycome, given the entire repertoire of
glycoconjugate-associated sugars in cells and tissues) is believed to be crucial
for the diverse roles of glycans, which are mediated by specific interactions
that control cell-cell adhesion, immune response, microbial pathogenesis and
other cellular events. The glycomic profile also reflects cellular alterations,
such as development, differentiation and cancerous change. A glycoconjugate-based
approach would therefore be expected to streamline discovery of novel cellular
biomarkers. Development of such an approach has proven challenging, due to the
technical difficulties associated with the analysis of various types of cellular
glycomes; however, recent progress in the development of analytical methodologies
and strategies has begun to clarify the cellular glycomics of various classes of
glycoconjugates. This review focuses on recent advances in the technical aspects
of cellular glycomic analyses of major classes of glycoconjugates, including N-
and O-linked glycans, derived from glycoproteins, proteoglycans and
glycosphingolipids. Articles that unveil the glycomics of various biologically
important cells, including embryonic and somatic stem cells, induced pluripotent
stem (iPS) cells and cancer cells, are discussed.
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