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2017 ; 6
(2
): 193-202
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Recent Trends in Clot Retrieval Devices: A Review
#MMPMID28702878
Hameed A
; Zafar H
; Mylotte D
; Sharif F
Cardiol Ther
2017[Dec]; 6
(2
): 193-202
PMID28702878
show ga
Stroke is the second leading cause of death worldwide and in Europe. Even with
gold standard medical management of acute ischemic stroke, which is intravenous
(IV) thrombolysis by administration of recombinant tissue plasminogen activator
(rt-PA), the mortality rate remains the same. Intra-arterial (IA) thrombolysis
therapy also did not achieve significant results and was not approved by the US
Food and Drug Administration (FDA) because of limited sample size. This
encouraged scientists and engineers to develop endovascular clot retrieval
devices for the mechanical recanalization of the occluded arteries in stroke
patients. Although the initial designs of clot retrieval devices failed, efforts
to improve these devices continue. Recently clot retrieval devices were approved
by the FDA as first-line treatment along with IV rt-PA. This article gives an
in-depth review of different clot retrieval devices which includes MERCI (the
first), the Penumbra Aspiration System, EmboTrap(®)II, stent retrievers, and the
way forward with the new FDA clearance of the devices as first-line treatment for
acute ischemic stroke along with IV rt-PA. The review also includes a comparison
of clot retrieval devices to gold standard treatment.
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