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10.1021/jacs.6b04614 http://scihub22266oqcxt.onion/10.1021/jacs.6b04614 C4976700!4976700 !27398798     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27398798 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Am+Chem+Soc 2016 ; 138 (28 ): 8920-7 Nephropedia Template TP {{tp|p=27398798 |t=2016. Real-Time Biological Annotation of Synthetic Compounds |pdf=|usr=}}{{27398798 }} gab.com Text Real-Time Biological Annotation of Synthetic Compounds JO: J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=27398798 #FOAvip Organic chemists are able to synthesize molecules in greater number and chemical complexity than ever before. Yet, a majority of these compounds go untested in biological systems, and those that do are often tested long after the chemist can incorporate the results into synthetic planning. We propose the use of high-dimensional "multiplex" assays, which are capable of measuring thousands of cellular features in one experiment, to annotate rapidly and inexpensively the biological activities of newly synthesized compounds. This readily accessible and inexpensive "real-time" profiling method can be used in a prospective manner to facilitate, for example, the efficient construction of performance-diverse small-molecule libraries that are enriched in bioactives. Here, we demonstrate this concept by synthesizing ten triads of constitutionally isomeric compounds via complexity-generating photochemical and thermal rearrangements and measuring compound-induced changes in cellular morphology via an imaging-based "cell painting" assay. Our results indicate that real-time biological annotation can inform optimization efforts and library syntheses by illuminating trends relating to biological activity that would be difficult to predict if only chemical structure were considered. We anticipate that probe and drug discovery will benefit from the use of optimization efforts and libraries that implement this approach. Twit Text FOAVip Real-Time Biological Annotation of Synthetic Compounds ????J Am Chem Soc http://www.kidney.de/pget.php?&tw=1&pmid=27398798 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27398798 #FOAvip English Wikipedia <ref>{{Cite pmid|27398798 }}</ref> Real-Time Biological Annotation of Synthetic Compounds #MMPMID27398798 Gerry CJ ; Hua BK ; Wawer MJ ; Knowles JP ; Nelson SD Jr ; Verho O ; Dandapani S ; Wagner BK ; Clemons PA ; Booker-Milburn KI ; Boskovic ZV ; Schreiber SL J Am Chem Soc 2016[Jul]; 138 (28 ): 8920-7 PMID27398798 show ga Organic chemists are able to synthesize molecules in greater number and chemical complexity than ever before. Yet, a majority of these compounds go untested in biological systems, and those that do are often tested long after the chemist can incorporate the results into synthetic planning. We propose the use of high-dimensional "multiplex" assays, which are capable of measuring thousands of cellular features in one experiment, to annotate rapidly and inexpensively the biological activities of newly synthesized compounds. This readily accessible and inexpensive "real-time" profiling method can be used in a prospective manner to facilitate, for example, the efficient construction of performance-diverse small-molecule libraries that are enriched in bioactives. Here, we demonstrate this concept by synthesizing ten triads of constitutionally isomeric compounds via complexity-generating photochemical and thermal rearrangements and measuring compound-induced changes in cellular morphology via an imaging-based "cell painting" assay. Our results indicate that real-time biological annotation can inform optimization efforts and library syntheses by illuminating trends relating to biological activity that would be difficult to predict if only chemical structure were considered. We anticipate that probe and drug discovery will benefit from the use of optimization efforts and libraries that implement this approach. |Chemistry Techniques, Synthetic [MESH] |Drug Evaluation, Preclinical/*methods [MESH] |Isomerism [MESH] |Photochemical Processes [MESH] |Small Molecule Libraries/chemical synthesis/*chemistry [MESH]Real-Time Biological Annotation of Synthetic Compounds (epmc).pdf DeepDyve Pubget Overpricing