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2015 ; 10
(2
): 109-111
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Real World Outcomes of Left Atrial Appendage Occlusion
#MMPMID29588685
Tzikas A
; Mylotte D
; Bergmann M
Interv Cardiol
2015[May]; 10
(2
): 109-111
PMID29588685
show ga
Percutaneous left atrial appendage occlusion (LAAO) is a device-based therapy for
the prevention of stroke in patients with non-valvular atrial fibrillation (AF).
Recently, the Watchman device (Boston Scientific, St Paul, MN, US) was approved
in the US by the Food and Drug Administration (FDA) based on the results of two
randomised clinical trials that evaluated LAAO in patients eligible for oral
anticoagulation (OAC) therapy. However, in real-word clinical practice LAAO is
typically offered to patients ineligible for OAC therapy, as they appear to have
limited treatment options and consequently worse prognosis. Although LAAO has
shown favourable clinical outcomes in OAC-ineligible patients in single or
multicentre observational studies, these results need to be confirmed in
randomised clinical trials.