Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23642229
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\23642229
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Annu+Rev+Biochem
2013 ; 82
(ä): 81-118
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Readout of epigenetic modifications
#MMPMID23642229
Patel DJ
; Wang Z
Annu Rev Biochem
2013[]; 82
(ä): 81-118
PMID23642229
show ga
This review focuses on a structure-based analysis of histone posttranslational
modification (PTM) readout, where the PTMs serve as docking sites for reader
modules as part of larger complexes displaying chromatin modifier and remodeling
activities, with the capacity to alter chromatin architecture and templated
processes. Individual topics addressed include the diversity of reader-binding
pocket architectures and common principles underlying readout of methyl-lysine
and methyl-arginine marks, their unmodified counterparts, as well as
acetyl-lysine and phosphoserine marks. The review also discusses the impact of
multivalent readout of combinations of PTMs localized at specific genomic sites
by linked binding modules on processes ranging from gene transcription to repair.
Additional topics include cross talk between histone PTMs, histone mimics,
epigenetic-based diseases, and drug-based therapeutic intervention. The review
ends by highlighting new initiatives and advances, as well as future challenges,
toward the promise of enhancing our structural and mechanistic understanding of
the readout of histone PTMs at the nucleosomal level.
|*Epigenesis, Genetic
[MESH]
|Chromatin Assembly and Disassembly/*genetics
[MESH]
free
free
free
