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10.4161/19490976.2014.969977 http://scihub22266oqcxt.onion/10.4161/19490976.2014.969977 C4615259!4615259 !25483334     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25483334 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Gut+Microbes 2014 ; 5 (5 ): 652-62 Nephropedia Template TP {{tp|p=25483334 |t=2014. Re-thinking the functions of IgA(+) plasma cells |pdf=|usr=}}{{25483334 }} gab.com Text Re-thinking the functions of IgA(+) plasma cells JO: Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=25483334 #FOAvip The intestinal mucosa harbors the largest population of antibody (Ab)-secreting plasma cells (PC) in the human body, producing daily several grams of immunoglobulin A (IgA). IgA has many functions, serving as a first-line barrier that protects the mucosal epithelium from pathogens, toxins and food antigens (Ag), shaping the intestinal microbiota, and regulating host-commensal homeostasis. Signals induced by commensal colonization are central for regulating IgA induction, maintenance, positioning and function and the number of IgA(+) PC is dramatically reduced in neonates and germ-free (GF) animals. Recent evidence demonstrates that the innate immune effector molecules tumor necrosis factor ? (TNF?) and inducible nitric oxide synthase (iNOS) are required for IgA(+) PC homeostasis during the steady state and infection. Moreover, new functions ascribed to PC independent of Ab secretion continue to emerge, suggesting that PC, including IgA(+) PC, should be re-examined in the context of inflammation and infection. Here, we outline mechanisms of IgA(+) PC generation and survival, reviewing their functions in health and disease. Twit Text FOAVip Re-thinking the functions of IgA(+) plasma cells ????Gut Microbes http://www.kidney.de/pget.php?&tw=1&pmid=25483334 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25483334 #FOAvip English Wikipedia <ref>{{Cite pmid|25483334 }}</ref> Re-thinking the functions of IgA(+) plasma cells #MMPMID25483334 Gommerman JL ; Rojas OL ; Fritz JH Gut Microbes 2014[]; 5 (5 ): 652-62 PMID25483334 show ga The intestinal mucosa harbors the largest population of antibody (Ab)-secreting plasma cells (PC) in the human body, producing daily several grams of immunoglobulin A (IgA). IgA has many functions, serving as a first-line barrier that protects the mucosal epithelium from pathogens, toxins and food antigens (Ag), shaping the intestinal microbiota, and regulating host-commensal homeostasis. Signals induced by commensal colonization are central for regulating IgA induction, maintenance, positioning and function and the number of IgA(+) PC is dramatically reduced in neonates and germ-free (GF) animals. Recent evidence demonstrates that the innate immune effector molecules tumor necrosis factor ? (TNF?) and inducible nitric oxide synthase (iNOS) are required for IgA(+) PC homeostasis during the steady state and infection. Moreover, new functions ascribed to PC independent of Ab secretion continue to emerge, suggesting that PC, including IgA(+) PC, should be re-examined in the context of inflammation and infection. Here, we outline mechanisms of IgA(+) PC generation and survival, reviewing their functions in health and disease. |Adaptive Immunity [MESH] |Animals [MESH] |Humans [MESH] |Immunity, Innate [MESH] |Immunoglobulin A/*immunology [MESH] |Intestinal Mucosa/*immunology [MESH]Re-thinking the functions of IgA(+) plasma cells (epmc).pdf DeepDyve Pubget Overpricing