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10.3390/biom4010315 http://scihub22266oqcxt.onion/10.3390/biom4010315 C4030989!4030989 !24970218     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24970218 &cmd=llinks): Failed to open stream: HTTP request failed! 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Re-configuration of sphingolipid metabolism by oncogenic transformation |pdf=|usr=}}{{24970218 }} gab.com Text Re-configuration of sphingolipid metabolism by oncogenic transformation JO: Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970218 #FOAvip The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses the synthesis of the pro-survival, pro-angiogenic metabolite sphingosine 1-phosphate (S1P), is well established as a hallmark of multiple cancers. Metabolic alterations that reduce levels of the pro-apoptotic lipid ceramide, particularly its glucosylation by glucosylceramide synthase (GCS), have frequently been associated with cancer drug resistance. However, the simple notion that the balance between ceramide and S1P, often referred to as the sphingolipid rheostat, dictates cell survival contrasts with recent studies showing that highly potent and selective SPHK1 inhibitors do not affect cancer cell proliferation or survival, and studies demonstrating higher ceramide levels in some metastatic cancers. Recent reports have implicated other sphingolipid metabolic enzymes such as acid sphingomyelinase (ASM) more strongly in cancer pathogenesis, and highlight lysosomal sphingolipid metabolism as a possible weak point for therapeutic targeting in cancer. This review describes the evidence implicating different sphingolipid metabolic enzymes and their products in cancer pathogenesis, and suggests how newer systems-level approaches may improve our overall understanding of how oncogenic transformation reconfigures sphingolipid metabolism. Twit Text FOAVip Re-configuration of sphingolipid metabolism by oncogenic transformation ????Biomolecules http://www.kidney.de/pget.php?&tw=1&pmid=24970218 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24970218 #FOAvip English Wikipedia <ref>{{Cite pmid|24970218 }}</ref> Re-configuration of sphingolipid metabolism by oncogenic transformation #MMPMID24970218 Don AS ; Lim XY ; Couttas TA Biomolecules 2014[Mar]; 4 (1 ): 315-53 PMID24970218 show ga The sphingolipids are one of the major lipid families in eukaryotes, incorporating a diverse array of structural variants that exert a powerful influence over cell fate and physiology. Increased expression of sphingosine kinase 1 (SPHK1), which catalyses the synthesis of the pro-survival, pro-angiogenic metabolite sphingosine 1-phosphate (S1P), is well established as a hallmark of multiple cancers. Metabolic alterations that reduce levels of the pro-apoptotic lipid ceramide, particularly its glucosylation by glucosylceramide synthase (GCS), have frequently been associated with cancer drug resistance. However, the simple notion that the balance between ceramide and S1P, often referred to as the sphingolipid rheostat, dictates cell survival contrasts with recent studies showing that highly potent and selective SPHK1 inhibitors do not affect cancer cell proliferation or survival, and studies demonstrating higher ceramide levels in some metastatic cancers. Recent reports have implicated other sphingolipid metabolic enzymes such as acid sphingomyelinase (ASM) more strongly in cancer pathogenesis, and highlight lysosomal sphingolipid metabolism as a possible weak point for therapeutic targeting in cancer. This review describes the evidence implicating different sphingolipid metabolic enzymes and their products in cancer pathogenesis, and suggests how newer systems-level approaches may improve our overall understanding of how oncogenic transformation reconfigures sphingolipid metabolism. |Animals [MESH] |Cell Transformation, Neoplastic/*metabolism [MESH] |Humans [MESH] |Lysophospholipids/metabolism [MESH] |Neoplasms/enzymology/*metabolism [MESH] |Sphingolipids/*metabolism [MESH]Re-configuration of sphingolipid metabolism by oncogenic transformatio(epmc).pdf DeepDyve Pubget Overpricing