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2013 ; 2013
(ä): 1119
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Raynaud s phenomenon (primary)
#MMPMID24112969
Pope J
BMJ Clin Evid
2013[Oct]; 2013
(ä): 1119
PMID24112969
show ga
INTRODUCTION: Raynaud's phenomenon is an episodic, reversible vasospasm of the
peripheral arteries (usually digital). It causes pallor, followed by cyanosis
and/or redness, often with pain and, at times, paraesthesia. On rare occasions,
it can lead to ulceration of the fingers and toes (and, in some cases, of the
ears or nose). This review focuses on primary (idiopathic) Raynaud's phenomenon,
occurring in the absence of an underlying disease. The prevalence of primary
Raynaud's phenomenon varies by sex, country, and exposure to workplace vibration.
METHODS AND OUTCOMES: We conducted a systematic review and aimed to answer the
following clinical question: What are the effects of drug treatments for primary
Raynaud's phenomenon? We searched: Medline, Embase, The Cochrane Library, and
other important databases up to August 2013 (Clinical Evidence reviews are
updated periodically; please check our website for the most up-to-date version of
this review). We included harms alerts from relevant organisations such as the US
Food and Drug Administration (FDA) and the UK Medicines and Healthcare products
Regulatory Agency (MHRA). RESULTS: We found 9 systematic reviews, RCTs, or
observational studies that met our inclusion criteria. We performed a GRADE
evaluation of the quality of evidence for interventions. CONCLUSIONS: In this
systematic review we present information relating to the effectiveness and safety
of the following interventions: amlodipine, diltiazem, nicardipine, and
nifedipine.