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2015 ; 21
(42
): 11954-63
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Rapid and quantitative detection of hepatitis B virus
#MMPMID26576084
Liu YP
; Yao CY
World J Gastroenterol
2015[Nov]; 21
(42
): 11954-63
PMID26576084
show ga
Despite availability of a universal vaccine, hepatitis B virus (HBV) infection
has a huge impact on public health worldwide. Accurate and timely diagnosis of
HBV infection is needed. Rapid developments have been made in the diagnostic and
monitoring methods for HBV infection, including serological and molecular assays.
In clinical practice, qualitative hepatitis B surface antigen (HBsAg) testing has
long served as a diagnostic marker for individuals infected with HBV. More
recently, HBsAg level has been used to predict treatment outcome when determined
early during treatment or at baseline. However, identification of HBV DNA
positive cases that do not have detectable HBsAg has encouraged the application
of molecular tests. Hence, combination of quantitative detection of HBV DNA and
HBsAg can be used to discriminate patients during the course of HBV infection and
to monitor therapy. This article reviews the most commonly used quantitative
methods for HBsAg and HBV DNA.
|*Immunologic Tests
[MESH]
|*Molecular Diagnostic Techniques
[MESH]
|Biomarkers/blood
[MESH]
|Biosensing Techniques
[MESH]
|DNA, Viral/*blood
[MESH]
|Hepatitis B Surface Antigens/*blood
[MESH]
|Hepatitis B virus/genetics/immunology/*isolation & purification
[MESH]
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