Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.21037/tau.2018.02.07 http://scihub22266oqcxt.onion/10.21037/tau.2018.02.07 C6043743!6043743 !30050802     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=30050802 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Transl+Androl+Urol 2018 ; 7 (3 ): 436-444 Nephropedia Template TP {{tp|p=30050802 |t=2018. Radium and other alpha emitters in prostate cancer |pdf=|usr=}}{{30050802 }} gab.com Text Radium and other alpha emitters in prostate cancer JO: Transl Androl Urol http://www.kidney.de/pget.php?&tw=1&pmid=30050802 #FOAvip (223)Radium ((223)Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that (223)Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate resistant prostate cancer patients. Though radium isotopic therapy is conceptually critical to demonstrate that alpha emitters can be safe and effective, (223)Ra has inherent limitations given its restriction to bone metastatic disease. To overcome this limitation, targeted alpha therapy (TAT) is now being actively evaluated in prostate cancer, and other neoplasms. Key to TAT in prostate tumors in current studies is the overexpression of prostate specific membrane antigen (PSMA), a folate hydrolase expressed on the cell surface of malignant adenocarcinomas of the prostate. Using PSMA targeting (small molecules or antibodies), alpha emitting agents such as (225)Actinium ((225)Ac) or (213)Bismuth ((213)Bi) can be delivered to PSMA expressing tumors regardless of their metastatic location. Initial results from TAT in prostate cancer are highly promising and rapid development of these agents is anticipated in the years ahead assuming adequacy of isotope availability and appropriate clinical trial design. TAT may be develop as an independent approach, or synergize with a variety of other approaches including external beam radiation, hormonal therapies, chemotherapies, various radiation sensitizers, DNA repair inhibitors, and/or immune modulators. Clinical investigation opportunities in this field will rapidly increase in the years ahead. Twit Text FOAVip Radium and other alpha emitters in prostate cancer ????Transl Androl Urol http://www.kidney.de/pget.php?&tw=1&pmid=30050802 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=30050802 #FOAvip English Wikipedia <ref>{{Cite pmid|30050802 }}</ref> Radium and other alpha emitters in prostate cancer #MMPMID30050802 Sartor O ; Sharma D Transl Androl Urol 2018[Jun]; 7 (3 ): 436-444 PMID30050802 show ga (223)Radium ((223)Ra) is the first alpha-emitting therapy proven effective in human cancer. Prospective randomized trials indicate that (223)Ra, which concentrates after intravenous injection in areas of osteoblastic metastatic disease, can prolong survival in bone-dominant castrate resistant prostate cancer patients. Though radium isotopic therapy is conceptually critical to demonstrate that alpha emitters can be safe and effective, (223)Ra has inherent limitations given its restriction to bone metastatic disease. To overcome this limitation, targeted alpha therapy (TAT) is now being actively evaluated in prostate cancer, and other neoplasms. Key to TAT in prostate tumors in current studies is the overexpression of prostate specific membrane antigen (PSMA), a folate hydrolase expressed on the cell surface of malignant adenocarcinomas of the prostate. Using PSMA targeting (small molecules or antibodies), alpha emitting agents such as (225)Actinium ((225)Ac) or (213)Bismuth ((213)Bi) can be delivered to PSMA expressing tumors regardless of their metastatic location. Initial results from TAT in prostate cancer are highly promising and rapid development of these agents is anticipated in the years ahead assuming adequacy of isotope availability and appropriate clinical trial design. TAT may be develop as an independent approach, or synergize with a variety of other approaches including external beam radiation, hormonal therapies, chemotherapies, various radiation sensitizers, DNA repair inhibitors, and/or immune modulators. Clinical investigation opportunities in this field will rapidly increase in the years ahead. ?Radium and other alpha emitters in prostate cancer (epmc).pdf DeepDyve Pubget Overpricing