Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534
Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24982880
.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Biomed+Res+Int
2014 ; 2014
(ä): 417091
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Radiopharmaceutical stem cell tracking for neurological diseases
#MMPMID24982880
Rosado-de-Castro PH
; Pimentel-Coelho PM
; Gutfilen B
; Lopes de Souza SA
; de Freitas GR
; Mendez-Otero R
; Barbosa da Fonseca LM
Biomed Res Int
2014[]; 2014
(ä): 417091
PMID24982880
show ga
Although neurological ailments continue to be some of the main causes of disease
burden in the world, current therapies such as pharmacological agents have
limited potential in the restoration of neural functions. Cell therapies, firstly
applied to treat different hematological diseases, are now being investigated in
preclinical and clinical studies for neurological illnesses. However, the
potential applications and mechanisms for such treatments are still poorly
comprehended and are the focus of permanent research. In this setting,
noninvasive in vivo imaging allows better understanding of several aspects of
stem cell therapies. Amongst the various methods available, radioisotope cell
labeling has become one of the most promising since it permits tracking of cells
after injection by different routes to investigate their biodistribution. A
significant increase in the number of studies utilizing this method has occurred
in the last years. Here, we review the different radiopharmaceuticals, imaging
techniques, and findings of the preclinical and clinical reports published up to
now. Moreover, we discuss the limitations and future applications of radioisotope
cell labeling in the field of cell transplantation for neurological diseases.
|*Radiopharmaceuticals
[MESH]
|Animals
[MESH]
|Cell Tracking/*methods
[MESH]
|Clinical Trials as Topic
[MESH]
|Humans
[MESH]
|Nervous System Diseases/*diagnostic imaging/*pathology
[MESH]