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Radioimmunotherapy of human tumours #MMPMID25998714
Larson SM; Carrasquillo JA; Cheung NKV; Press O
Nat Rev Cancer 2015[Jun]; 15 (6): 347-60 PMID25998714show ga
Eradication of cancer remains a vexing problem despite recent advances in our understanding of the molecular basis of neoplasia. One therapeutic approach that has demonstrated potential involves the selective targeting of radionuclides to cancer-associated cell surface antigens using monoclonal antibodies. Such radioimmunotherapy (RIT) permits the delivery of a high dose of therapeutic radiation to cancer cells, while minimizing the exposure of normal cells. Although this approach has been investigated for several decades, the cumulative advances in cancer biology, antibody engineering, and radiochemistry in the last decade has markedly enhanced the ability of RIT to produce durable remissions of multiple cancer types.