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10.18632/oncotarget.7878 http://scihub22266oqcxt.onion/10.18632/oncotarget.7878 C4991492!4991492 !26959112     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=26959112 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26959112 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (15 ): 20788-800 Nephropedia Template TP {{tp|p=26959112 |t=2016. Radiation therapy generates platelet-activating factor agonists |pdf=|usr=}}{{26959112 }} gab.com Text Radiation therapy generates platelet-activating factor agonists JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26959112 #FOAvip Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the present studies were designed to define whether ionizing radiation could generate PAF-R agonists and if these lipids could subvert host immunity. We demonstrate that radiation exposure of multiple tumor cell lines in-vitro, tumors in-vivo, and human subjects undergoing radiation therapy for skin tumors all generate PAF-R agonists. Structural characterization of radiation-induced PAF-R agonistic activity revealed PAF and multiple oxidized glycerophosphocholines that are produced non-enzymatically. In a murine melanoma tumor model, irradiation of one tumor augmented the growth of the other (non-treated) tumor in a PAF-R-dependent process blocked by a cyclooxygenase-2 inhibitor. These results indicate a novel pathway by which PAF-R agonists produced as a byproduct of radiation therapy could result in tumor treatment failure, and offer important insights into potential therapeutic strategies that could improve the overall antitumor effectiveness of radiation therapy regimens. Twit Text FOAVip Radiation therapy generates platelet-activating factor agonists ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=26959112 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26959112 #FOAvip English Wikipedia <ref>{{Cite pmid|26959112 }}</ref> Radiation therapy generates platelet-activating factor agonists #MMPMID26959112 Sahu RP ; Harrison KA ; Weyerbacher J ; Murphy RC ; Konger RL ; Garrett JE ; Chin-Sinex HJ ; Johnston ME 2nd ; Dynlacht JR ; Mendonca M ; McMullen K ; Li G ; Spandau DF ; Travers JB Oncotarget 2016[Apr]; 7 (15 ): 20788-800 PMID26959112 show ga Pro-oxidative stressors can suppress host immunity due to their ability to generate oxidized lipid agonists of the platelet-activating factor-receptor (PAF-R). As radiation therapy also induces reactive oxygen species, the present studies were designed to define whether ionizing radiation could generate PAF-R agonists and if these lipids could subvert host immunity. We demonstrate that radiation exposure of multiple tumor cell lines in-vitro, tumors in-vivo, and human subjects undergoing radiation therapy for skin tumors all generate PAF-R agonists. Structural characterization of radiation-induced PAF-R agonistic activity revealed PAF and multiple oxidized glycerophosphocholines that are produced non-enzymatically. In a murine melanoma tumor model, irradiation of one tumor augmented the growth of the other (non-treated) tumor in a PAF-R-dependent process blocked by a cyclooxygenase-2 inhibitor. These results indicate a novel pathway by which PAF-R agonists produced as a byproduct of radiation therapy could result in tumor treatment failure, and offer important insights into potential therapeutic strategies that could improve the overall antitumor effectiveness of radiation therapy regimens. |*Ultraviolet Rays [MESH] |Animals [MESH] |Antioxidants/*pharmacology [MESH] |Female [MESH] |Humans [MESH] |Melanoma/immunology/metabolism/pathology/*therapy [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Mice, Nude [MESH] |Oxidative Stress [MESH] |Platelet Activating Factor/*agonists [MESH] |Platelet Membrane Glycoproteins/*agonists/physiology [MESH] |Receptors, G-Protein-Coupled/*agonists/physiology [MESH] |Signal Transduction [MESH] |Skin Neoplasms/immunology/metabolism/secondary/*therapy [MESH] |Tumor Cells, Cultured [MESH]Radiation therapy generates platelet-activating factor agonists (epmc).pdf DeepDyve Pubget Overpricing