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10.1016/j.canlet.2015.03.031 http://scihub22266oqcxt.onion/10.1016/j.canlet.2015.03.031 C4578968!4578968 !25819030     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25819030 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25819030 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Cancer+Lett 2015 ; 368 (2 ): 238-45 Nephropedia Template TP {{tp|p=25819030 |t=2015. Radiation takes its Toll |pdf=|usr=}}{{25819030 }} gab.com Text Radiation takes its Toll JO: Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=25819030 #FOAvip The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able to mount a response that is appropriate to the danger. Toll-like receptors are at the heart of this pattern recognition system that initiates innate pro-oxidant, pro-inflammatory signaling cascades and ultimately bridges recognition of danger to adaptive immunity. The acute inflammatory lesions that are formed segue into resolution of inflammation, repair and healing or, more dysfunctionally, into chronic inflammation, autoimmunity, excessive tissue damage and carcinogenesis. Redox is at the nexus of this decision making process and is the point at which ionizing radiation initially intercepts to trigger similar responses to self-damage. In this review we discuss our current understanding of how radiation-damaged cells interact with Toll-like receptors and how the immune systems interprets these radiation-induced danger signals in the context of whole-body exposures and during local tumor irradiation. Twit Text FOAVip Radiation takes its Toll ????Cancer Lett http://www.kidney.de/pget.php?&tw=1&pmid=25819030 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25819030 #FOAvip English Wikipedia <ref>{{Cite pmid|25819030 }}</ref> Radiation takes its Toll #MMPMID25819030 Ratikan JA ; Micewicz ED ; Xie MW ; Schaue D Cancer Lett 2015[Nov]; 368 (2 ): 238-45 PMID25819030 show ga The ability to recognize and respond to universal molecular patterns on invading microorganisms allows our immune system to stay on high alert, sensing danger to our self-integrity. Our own damaged cells and tissues in pathological situations activate similar warning systems as microbes. In this way, the body is able to mount a response that is appropriate to the danger. Toll-like receptors are at the heart of this pattern recognition system that initiates innate pro-oxidant, pro-inflammatory signaling cascades and ultimately bridges recognition of danger to adaptive immunity. The acute inflammatory lesions that are formed segue into resolution of inflammation, repair and healing or, more dysfunctionally, into chronic inflammation, autoimmunity, excessive tissue damage and carcinogenesis. Redox is at the nexus of this decision making process and is the point at which ionizing radiation initially intercepts to trigger similar responses to self-damage. In this review we discuss our current understanding of how radiation-damaged cells interact with Toll-like receptors and how the immune systems interprets these radiation-induced danger signals in the context of whole-body exposures and during local tumor irradiation. |Humans [MESH] |Immune System/immunology/radiation effects [MESH] |Inflammation/immunology/metabolism [MESH] |Radiation Injuries/immunology/*metabolism/pathology [MESH] |Reactive Oxygen Species/metabolism [MESH]Radiation takes its Toll (epmc).pdf DeepDyve Pubget Overpricing