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10.18632/oncotarget.11654 http://scihub22266oqcxt.onion/10.18632/oncotarget.11654 C5325402!5325402 !27572318     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\27572318 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Oncotarget 2016 ; 7 (39 ): 63767-63778 Nephropedia Template TP {{tp|p=27572318 |t=2016. RSPOs facilitated HSC activation and promoted hepatic fibrogenesis |pdf=|usr=}}{{27572318 }} gab.com Text RSPOs facilitated HSC activation and promoted hepatic fibrogenesis JO: Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27572318 #FOAvip Roof plate-specific spondin (RSPO) proteins are potent Wnt pathway agonists and involve in a broad range of developmental and physiological processes. This study investigated the activities and mechanisms of RSPOs in liver fibrogenesis, especially in hepatic stellate cell (HSC) activation. HSC activation was assessed by fibrosis biomarker (?-smooth muscle actin and Collagen-I), phenotypic change (accumulation of lipid droplets), and increased proliferation. Similarly, Wnt pathway activity was evaluated by the expression of nuclear ?-catenin and T cell-specific transcription factors (TCF) activity. We found RSPOs were overexpressed in human fibrotic liver tissue and the expressions were correlated with liver fibrosis stages. In vitro studies showed RSPOs level increased during HSC activation, and stimuli with RSPOs enhanced Wnt pathway activity and promoted HSC activation subsequently. Furthermore, in vivo experiments demonstrated that the knockdown of RSPOs suppressed both Wnt pathway activity and HSC activation. Interestingly, the inhibitor of the Wnt signaling pathway Dickkopf1 impairs RSPOs effects on HSCs. Taken together, our results revealed that RSPOs facilitated HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway. Twit Text FOAVip RSPOs facilitated HSC activation and promoted hepatic fibrogenesis ????Oncotarget http://www.kidney.de/pget.php?&tw=1&pmid=27572318 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=27572318 #FOAvip English Wikipedia <ref>{{Cite pmid|27572318 }}</ref> RSPOs facilitated HSC activation and promoted hepatic fibrogenesis #MMPMID27572318 Yin X ; Yi H ; Wang L ; Wu W ; Wu X ; Yu L Oncotarget 2016[Sep]; 7 (39 ): 63767-63778 PMID27572318 show ga Roof plate-specific spondin (RSPO) proteins are potent Wnt pathway agonists and involve in a broad range of developmental and physiological processes. This study investigated the activities and mechanisms of RSPOs in liver fibrogenesis, especially in hepatic stellate cell (HSC) activation. HSC activation was assessed by fibrosis biomarker (?-smooth muscle actin and Collagen-I), phenotypic change (accumulation of lipid droplets), and increased proliferation. Similarly, Wnt pathway activity was evaluated by the expression of nuclear ?-catenin and T cell-specific transcription factors (TCF) activity. We found RSPOs were overexpressed in human fibrotic liver tissue and the expressions were correlated with liver fibrosis stages. In vitro studies showed RSPOs level increased during HSC activation, and stimuli with RSPOs enhanced Wnt pathway activity and promoted HSC activation subsequently. Furthermore, in vivo experiments demonstrated that the knockdown of RSPOs suppressed both Wnt pathway activity and HSC activation. Interestingly, the inhibitor of the Wnt signaling pathway Dickkopf1 impairs RSPOs effects on HSCs. Taken together, our results revealed that RSPOs facilitated HSC activation and promote liver fibrogenesis by enhancing the Wnt pathway. |Aged [MESH] |Animals [MESH] |Cell Nucleus/metabolism [MESH] |Cell Proliferation [MESH] |Coculture Techniques [MESH] |Collagen Type I/metabolism [MESH] |Female [MESH] |Gene Expression Regulation [MESH] |Hepatic Stellate Cells/*cytology/metabolism [MESH] |Humans [MESH] |Intercellular Signaling Peptides and Proteins/*metabolism [MESH] |Liver Cirrhosis/metabolism/*pathology [MESH] |Male [MESH] |Mice [MESH] |Middle Aged [MESH] |Signal Transduction [MESH] |Thrombospondins/*metabolism [MESH] |Wnt Proteins/metabolism [MESH] |Wnt Signaling Pathway/drug effects [MESH]RSPOs facilitated HSC activation and promoted hepatic fibrogenesis (epmc).pdf DeepDyve Pubget Overpricing