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10.1016/j.molmed.2017.03.004 http://scihub22266oqcxt.onion/10.1016/j.molmed.2017.03.004 C5462452!5462452 !28427863     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=28427863 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\28427863 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Trends+Mol+Med 2017 ; 23 (5 ): 411-429 Nephropedia Template TP {{tp|p=28427863 |t=2017. ROS in Cancer: The Burning Question |pdf=|usr=}}{{28427863 }} gab.com Text ROS in Cancer: The Burning Question JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28427863 #FOAvip An unanswered question in human health is whether antioxidation prevents or promotes cancer. Antioxidation has historically been viewed as chemopreventive, but emerging evidence suggests that antioxidants may be supportive of neoplasia. We posit this contention to be rooted in the fact that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells. This cautions against therapeutic strategies to increase ROS at a global level. To leverage redox alterations towards the development of effective therapies necessitates the application of biophysical and biochemical approaches to define redox dynamics and to functionally elucidate specific oxidative modifications in cancer versus normal cells. An improved understanding of the sophisticated workings of redox biology is imperative to defeating cancer. Twit Text FOAVip ROS in Cancer: The Burning Question ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=28427863 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=28427863 #FOAvip English Wikipedia <ref>{{Cite pmid|28427863 }}</ref> ROS in Cancer: The Burning Question #MMPMID28427863 Chio IIC ; Tuveson DA Trends Mol Med 2017[May]; 23 (5 ): 411-429 PMID28427863 show ga An unanswered question in human health is whether antioxidation prevents or promotes cancer. Antioxidation has historically been viewed as chemopreventive, but emerging evidence suggests that antioxidants may be supportive of neoplasia. We posit this contention to be rooted in the fact that ROS do not operate as one single biochemical entity, but as diverse secondary messengers in cancer cells. This cautions against therapeutic strategies to increase ROS at a global level. To leverage redox alterations towards the development of effective therapies necessitates the application of biophysical and biochemical approaches to define redox dynamics and to functionally elucidate specific oxidative modifications in cancer versus normal cells. An improved understanding of the sophisticated workings of redox biology is imperative to defeating cancer. |Animals [MESH] |Antioxidants/*metabolism [MESH] |Humans [MESH] |Neoplasms/genetics/*metabolism [MESH] |Oxidation-Reduction [MESH] |Oxidative Stress/genetics/physiology [MESH]ROS in Cancer: The Burning Question (epmc).pdf DeepDyve Pubget Overpricing