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10.1007/978-1-4939-1221-6_10 http://scihub22266oqcxt.onion/10.1007/978-1-4939-1221-6_10 C4483269!4483269 !25201111     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25201111 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Adv+Exp+Med+Biol 2014 ; 825 (ä): 353-88 Nephropedia Template TP {{tp|p=25201111 |t=2014. RNA-binding protein misregulation in microsatellite expansion disorders |pdf=|usr=}}{{25201111 }} gab.com Text RNA-binding protein misregulation in microsatellite expansion disorders JO: Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=25201111 #FOAvip RNA-binding proteins (RBPs) play pivotal roles in multiple cellular pathways from transcription to RNA turnover by interacting with RNA sequence and/or structural elements to form distinct RNA-protein complexes. Since these complexes are required for the normal regulation of gene expression, mutations that alter RBP functions may result in a cascade of deleterious events that lead to severe disease. Here, we focus on a group of hereditary disorders, the microsatellite expansion diseases, which alter RBP activities and result in abnormal neurological and neuromuscular phenotypes. While many of these diseases are classified as adult-onset disorders, mounting evidence indicates that disruption of normal RNA-protein interaction networks during embryogenesis modifies developmental pathways, which ultimately leads to disease manifestations later in life. Efforts to understand the molecular basis of these disorders has already uncovered novel pathogenic mechanisms, including RNA toxicity and repeat-associated non-ATG (RAN) translation, and current studies suggest that additional surprising insights into cellular regulatory pathways will emerge in the future. Twit Text FOAVip RNA-binding protein misregulation in microsatellite expansion disorders ????Adv Exp Med Biol http://www.kidney.de/pget.php?&tw=1&pmid=25201111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25201111 #FOAvip English Wikipedia <ref>{{Cite pmid|25201111 }}</ref> RNA-binding protein misregulation in microsatellite expansion disorders #MMPMID25201111 Goodwin M ; Swanson MS Adv Exp Med Biol 2014[]; 825 (ä): 353-88 PMID25201111 show ga RNA-binding proteins (RBPs) play pivotal roles in multiple cellular pathways from transcription to RNA turnover by interacting with RNA sequence and/or structural elements to form distinct RNA-protein complexes. Since these complexes are required for the normal regulation of gene expression, mutations that alter RBP functions may result in a cascade of deleterious events that lead to severe disease. Here, we focus on a group of hereditary disorders, the microsatellite expansion diseases, which alter RBP activities and result in abnormal neurological and neuromuscular phenotypes. While many of these diseases are classified as adult-onset disorders, mounting evidence indicates that disruption of normal RNA-protein interaction networks during embryogenesis modifies developmental pathways, which ultimately leads to disease manifestations later in life. Efforts to understand the molecular basis of these disorders has already uncovered novel pathogenic mechanisms, including RNA toxicity and repeat-associated non-ATG (RAN) translation, and current studies suggest that additional surprising insights into cellular regulatory pathways will emerge in the future. |*DNA Repeat Expansion [MESH] |*Microsatellite Repeats [MESH] |Animals [MESH] |Heredodegenerative Disorders, Nervous System/*genetics/*metabolism/pathology [MESH] |Humans [MESH]RNA-binding protein misregulation in microsatellite expansion disorder(epmc).pdf DeepDyve Pubget Overpricing