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2014 ; 11
(8
): 1051-60
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RNA localization in bacteria
#MMPMID25482897
Buskila AA
; Kannaiah S
; Amster-Choder O
RNA Biol
2014[]; 11
(8
): 1051-60
PMID25482897
show ga
One of the most important discoveries in the field of microbiology in the last
two decades is that bacterial cells have intricate subcellular organization. This
understanding has emerged mainly from the depiction of spatial and temporal
organization of proteins in specific domains within bacterial cells, e.g.,
midcell, cell poles, membrane and periplasm. Because translation of bacterial RNA
molecules was considered to be strictly coupled to their synthesis, they were not
thought to specifically localize to regions outside the nucleoid. However, the
increasing interest in RNAs, including non-coding RNAs, encouraged researchers to
explore the spatial and temporal localization of RNAs in bacteria. The recent
technological improvements in the field of fluorescence microscopy allowed
subcellular imaging of RNAs even in the tiny bacterial cells. It has been
reported by several groups, including ours that transcripts may specifically
localize in such cells. Here we review what is known about localization of RNA
and of the pathways that determine RNA fate in bacteria, and discuss the possible
cues and mechanisms underlying these distribution patterns.
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