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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 J+Gene+Med
2006 ; 8
(8
): 933-50
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RNA interference for antiviral therapy
#MMPMID16779870
Ketzinel-Gilad M
; Shaul Y
; Galun E
J Gene Med
2006[Aug]; 8
(8
): 933-50
PMID16779870
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Silencing gene expression through a process known as RNA interference (RNAi) has
been known in the plant world for many years. In recent years, knowledge of the
prevalence of RNAi and the mechanism of gene silencing through RNAi has started
to unfold. It is now believed that RNAi serves in part as an innate response
against invading viral pathogens and, indeed, counter silencing mechanisms aimed
at neutralizing RNAi have been found in various viral pathogens. During the past
few years, it has been demonstrated that RNAi, induced by specifically designed
double-stranded RNA (dsRNA) molecules, can silence gene expression of human viral
pathogens both in acute and chronic viral infections. Furthermore, it is now
apparent that in in vitro and in some in vivo models, the prospects for this
technology in developing therapeutic applications are robust. However, many key
questions and obstacles in the translation of RNAi into a potential therapeutic
platform still remain, including the specificity and longevity of the silencing
effect, and, most importantly, the delivery of the dsRNA that induces the system.
It is expected that for the specific examples in which the delivery issue could
be circumvented or resolved, RNAi may hold promise for the development of
gene-specific therapeutics.
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