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RNA Regulation by Poly(ADP-Ribose) Polymerases
#MMPMID26091344
Bock FJ
; Todorova TT
; Chang P
Mol Cell
2015[Jun]; 58
(6
): 959-69
PMID26091344
show ga
Posttranscriptional regulation of RNA facilitates the fine-tuning of gene
expression. It occurs through multiple pathways that include the nuclear
processing of mRNA and its precursors, mRNA silencing, regulation of mRNA decay,
and regulation of translation. Poly(ADP-ribose) polymerases (PARPs), enzymes that
modify target proteins with ADP-ribose, play important roles in many of the RNA
regulatory pathways through multiple mechanisms. For example, RNA-binding PARPs
can target specific transcripts for regulation; ADP-ribosylation of
RNA-regulatory proteins can alter their localization, activity, or RNA binding;
and noncovalent interactions of RNA-binding proteins with poly(ADP-ribose) can
affect their function. In addition to regulating RNA during non-stress
conditions, PARPs regulate RNA function during cellular stress conditions that
are critical for the proper execution of a stress response. In this review, we
summarize the current knowledge regarding PARP-dependent regulation of RNAs, and
describe how by modulating RNA processing, translation, and decay PARPs impact
multiple processes in the cell.
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