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2016 ; 61
(4
): 496-505
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RNA Processing and Genome Stability: Cause and Consequence
#MMPMID26895423
Wickramasinghe VO
; Venkitaraman AR
Mol Cell
2016[Feb]; 61
(4
): 496-505
PMID26895423
show ga
It is emerging that the pathways that process newly transcribed RNA molecules
also regulate the response to DNA damage at multiple levels. Here, we discuss
recent insights into how RNA processing pathways participate in DNA damage
recognition, signaling, and repair, selectively influence the expression of
genome-stabilizing proteins, and resolve deleterious DNA/RNA hybrids (R-loops)
formed during transcription and RNA processing. The importance of these pathways
for the DNA damage response (DDR) is underscored by the growing appreciation that
defects in these regulatory connections may be connected to the genome
instability involved in several human diseases, including cancer.