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10.1080/23723556.2017.1345711

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suck abstract from ncbi


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pmid29057308
      Mol+Cell+Oncol 2017 ; 4 (5 ): e1345711
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  • RAS oncogenes direct metastasis #MMPMID29057308
  • Spella M ; Marazioti A ; Arendt KAM ; Stathopoulos GT
  • Mol Cell Oncol 2017[]; 4 (5 ): e1345711 PMID29057308 show ga
  • RAS genes are cardinal driver oncogenes frequently and differentially mutated across bodily tumors. Their tumorigenic potential has been mainly ascribed to autonomous promotion of tumor cell proliferation and survival. However, recent evidence shows that RAS oncogenes also function to define metastatic tropism. Interestingly, RAS-driven metastasis is mediated by distinct chemokine sets that signal to endothelial and myeloid cells.
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