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Quorum protection, growth and survival
#MMPMID28357274
Macreadie IG
Microb Cell
2015[Jan]; 2
(2
): 38-42
PMID28357274
show ga
For the growth of a cell culture, one inoculates not with one cell but with a
quorum of cells. This most often a requirement, not just a convenience, and most
of us take this for granted without question. Here this observation is
re-examined to understand why a quorum may be required to grow cells. The
importance of quorums may be widespread in the aspects of microbiology they
affect. It is very likely that quorums are connected with and have a large impact
on the determination of Minimal Inhibitory Concentrations. It is also possible
that low cell density may adversely affect cell survival, however, this is an
area where even less is known. The need for a quorum might affect other aspects
of microbial cell culture, cell isolation and cell preservation. Effects also
extend to mammalian cell culture. Here I seek to review studies that have been
documented and speculate on how the information might be utilized in the future.
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