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2015 ; 5
(3
): 166-71
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Quetiapine versus aripiprazole in the management of schizophrenia
#MMPMID26199719
Shoja Shafti S
; Kaviani H
Ther Adv Psychopharmacol
2015[Jun]; 5
(3
): 166-71
PMID26199719
show ga
OBJECTIVES: Current evidence supports the use of various second-generation
antipsychotics for pharmacotherapy of schizophrenia. While in a systematic
review, generally no difference in efficacy was found between atypical
antipsychotics, other studies have found quetiapine less effective than
aripiprazole. This article reviews the efficacy and tolerability of aripiprazole
versus quetiapine in the context of recommended management strategies for
schizophrenia. METHOD: Fifty female inpatients, meeting the diagnosis of
schizophrenia, were randomly entered into two groups (n = 25 in each group) to
participate in a 12-week, double-blind study for random assignment to quetiapine
or aripiprazole. The primary outcome measures were Scale for Assessment of
Positive Symptoms and Scale for Assessment of Negative Symptoms. The schedule for
Assessment of Insight (SAI), Clinical Global Impressions Severity Scale (CGI-S)
and the Simpson Angus Scale (SAS) were also used as secondary measures. RESULTS:
Both quetiapine and aripiprazole showed significant effectiveness in the
improvement of positive symptoms. The effectiveness for negative symptoms was
also noteworthy with both drugs, although not to a significant level during this
study. In addition, significant improvement was found on assessment with CGI-S
and SAI for quetiapine and aripiprazole. SAS did not show any important increment
in extrapyramidal side effects at the end of the examination. CONCLUSION:
According to the findings, quetiapine and aripiprazole had similar effectiveness
and tolerability with respect to management of schizophrenia.