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10.1103/PhysRevE.78.061921 http://scihub22266oqcxt.onion/10.1103/PhysRevE.78.061921 C4478466!4478466 !19256882     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\19256882 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Phys+Rev+E+Stat+Nonlin+Soft+Matter+Phys 2008 ; 78 (6 Pt 1 ): 061921 Nephropedia Template TP {{tp|p=19256882 |t=2008. Quasispecies theory for horizontal gene transfer and recombination |pdf=|usr=}}{{19256882 }} gab.com Text Quasispecies theory for horizontal gene transfer and recombination JO: Phys Rev E Stat Nonlin Soft Matter Phys http://www.kidney.de/pget.php?&tw=1&pmid=19256882 #FOAvip We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a population. We study the effect of different schemes of genetic recombination on the steady-state mean fitness and distribution of individuals in the population, through an analytic field theoretic mapping. We investigate both horizontal gene transfer from a population and recombination between pairs of individuals. Somewhat surprisingly, these nonlinear generalizations of quasispecies theory to modern biology are analytically solvable. For two-parent recombination, we find two selected phases, one of which is spectrally rigid. We present exact analytical formulas for the equilibrium mean fitness of the population, in terms of a maximum principle, which are generally applicable to any permutation invariant replication rate function. For smooth fitness landscapes, we show that when positive epistatic interactions are present, recombination or horizontal gene transfer introduces a mild load against selection. Conversely, if the fitness landscape exhibits negative epistasis, horizontal gene transfer or recombination introduces an advantage by enhancing selection towards the fittest genotypes. These results prove that the mutational deterministic hypothesis holds for quasispecies models. For the discontinuous single sharp peak fitness landscape, we show that horizontal gene transfer has no effect on the fitness, while recombination decreases the fitness, for both the parallel and the Eigen models. We present numerical and analytical results as well as phase diagrams for the different cases. Twit Text FOAVip Quasispecies theory for horizontal gene transfer and recombination ????Phys Rev E Stat Nonlin Soft Matter Phys http://www.kidney.de/pget.php?&tw=1&pmid=19256882 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=19256882 #FOAvip English Wikipedia <ref>{{Cite pmid|19256882 }}</ref> Quasispecies theory for horizontal gene transfer and recombination #MMPMID19256882 Muņoz E ; Park JM ; Deem MW Phys Rev E Stat Nonlin Soft Matter Phys 2008[Dec]; 78 (6 Pt 1 ): 061921 PMID19256882 show ga We introduce a generalization of the parallel, or Crow-Kimura, and Eigen models of molecular evolution to represent the exchange of genetic information between individuals in a population. We study the effect of different schemes of genetic recombination on the steady-state mean fitness and distribution of individuals in the population, through an analytic field theoretic mapping. We investigate both horizontal gene transfer from a population and recombination between pairs of individuals. Somewhat surprisingly, these nonlinear generalizations of quasispecies theory to modern biology are analytically solvable. For two-parent recombination, we find two selected phases, one of which is spectrally rigid. We present exact analytical formulas for the equilibrium mean fitness of the population, in terms of a maximum principle, which are generally applicable to any permutation invariant replication rate function. For smooth fitness landscapes, we show that when positive epistatic interactions are present, recombination or horizontal gene transfer introduces a mild load against selection. Conversely, if the fitness landscape exhibits negative epistasis, horizontal gene transfer or recombination introduces an advantage by enhancing selection towards the fittest genotypes. These results prove that the mutational deterministic hypothesis holds for quasispecies models. For the discontinuous single sharp peak fitness landscape, we show that horizontal gene transfer has no effect on the fitness, while recombination decreases the fitness, for both the parallel and the Eigen models. We present numerical and analytical results as well as phase diagrams for the different cases. |*Gene Transfer, Horizontal [MESH] |*Models, Genetic [MESH] |*Recombination, Genetic [MESH] |Biophysical Phenomena [MESH] |Epistasis, Genetic [MESH] |Evolution, Molecular [MESH] |Mutation [MESH] |Nonlinear Dynamics [MESH]Quasispecies theory for horizontal gene transfer and recombination (epmc).pdf DeepDyve Pubget Overpricing