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2017 ; 13
(ä): 1-7
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Quantitative biology of hydrogen peroxide signaling
#MMPMID28528123
Antunes F
; Brito PM
Redox Biol
2017[Oct]; 13
(ä): 1-7
PMID28528123
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Hydrogen peroxide (H(2)O(2)) controls signaling pathways in cells by oxidative
modulation of the activity of redox sensitive proteins denominated redox
switches. Here, quantitative biology concepts are applied to review how H(2)O(2)
fulfills a key role in information transmission. Equations described lay the
foundation of H(2)O(2) signaling, give new insights on H(2)O(2) signaling
mechanisms, and help to learn new information from common redox signaling
experiments. A key characteristic of H(2)O(2) signaling is that the ratio between
reduction and oxidation of redox switches determines the range of H(2)O(2)
concentrations to which they respond. Thus, a redox switch with low
H(2)O(2)-dependent oxidability and slow reduction rate responds to the same range
of H(2)O(2) concentrations as a redox switch with high H(2)O(2)-dependent
oxidability, but that is rapidly reduced. Yet, in the first case the response
time is slow while in the second case is rapid. H(2)O(2) sensing and transmission
of information can be done directly or by complex mechanisms in which oxidation
is relayed between proteins before oxidizing the final regulatory redox target.
In spite of being a very simple molecule, H(2)O(2) has a key role in cellular
signaling, with the reliability of the information transmitted depending on the
inherent chemical reactivity of redox switches, on the presence of localized
H(2)O(2) pools, and on the molecular recognition between redox switches and their
partners.
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