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2015 ; 5
(ä): 11598
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Quantitative analysis of the human T cell palmitome
#MMPMID26111759
Morrison E
; Kuropka B
; Kliche S
; Brügger B
; Krause E
; Freund C
Sci Rep
2015[Jun]; 5
(ä): 11598
PMID26111759
show ga
Palmitoylation is a reversible post-translational modification used to inducibly
compartmentalize proteins in cellular membranes, affecting the function of
receptors and intracellular signaling proteins. The identification of protein
"palmitomes" in several cell lines raises the question to what extent this
modification is conserved in primary cells. Here we use primary T cells with
acyl-biotin exchange and quantitative mass spectrometry to identify a pool of
proteins previously unreported as palmitoylated in vivo.