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10.1242/jcs.166629 http://scihub22266oqcxt.onion/10.1242/jcs.166629 C4446733!4446733 !25770102     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25770102 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       J+Cell+Sci 2015 ; 128 (9 ): 1655-60 Nephropedia Template TP {{tp|p=25770102 |t=2015. Pyruvate kinase M2 at a glance |pdf=|usr=}}{{25770102 }} gab.com Text Pyruvate kinase M2 at a glance JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25770102 #FOAvip Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment. Twit Text FOAVip Pyruvate kinase M2 at a glance ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=25770102 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25770102 #FOAvip English Wikipedia <ref>{{Cite pmid|25770102 }}</ref> Pyruvate kinase M2 at a glance #MMPMID25770102 Yang W ; Lu Z J Cell Sci 2015[May]; 128 (9 ): 1655-60 PMID25770102 show ga Reprogrammed metabolism is a key feature of cancer cells. The pyruvate kinase M2 (PKM2) isoform, which is commonly upregulated in many human cancers, has been recently shown to play a crucial role in metabolism reprogramming, gene transcription and cell cycle progression. In this Cell Science at a glance article and accompanying poster, we provide a brief overview of recent advances in understanding the mechanisms underlying the regulation of PKM2 expression, enzymatic activity, metabolic functions and subcellular location. We highlight the instrumental role of the non-metabolic functions of PKM2 in tumorigenesis and evaluate the potential to target PKM2 for cancer treatment. |Animals [MESH] |Humans [MESH] |Molecular Targeted Therapy [MESH] |Neoplasms/drug therapy/metabolism [MESH]Pyruvate kinase M2 at a glance (epmc).pdf DeepDyve Pubget Overpricing