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Pyrroloquinoline-quinone suppresses liver fibrogenesis in mice
#MMPMID25822822
Jia D
; Duan F
; Peng P
; Sun L
; Ruan Y
; Gu J
PLoS One
2015[]; 10
(3
): e0121939
PMID25822822
show ga
Liver fibrosis represents the consequences of a sustained wound healing response
to chronic liver injuries, and its progression toward cirrhosis is the major
cause of liver-related morbidity and mortality worldwide. However, anti-fibrotic
treatment remains an unconquered area for drug development. Accumulating evidence
indicate that oxidative stress plays a critical role in liver fibrogenesis. In
this study, we found that PQQ, a natural anti-oxidant present in a wide variety
of human foods, exerted potent anti-fibrotic and ROS-scavenging activity in
Balb/C mouse models of liver fibrosis. The antioxidant activity of PQQ was
involved in the modulation of multiple steps during liver fibrogenesis, including
chronic liver injury, hepatic inflammation, as well as activation of hepatic
stellate cells and production of extracellular matrix. PQQ also suppressed the
up-regulation of RACK1 in activated HSCs in vivo and in vitro. Our data suggest
that PQQ suppresses oxidative stress and liver fibrogenesis in mice, and provide
rationale for the clinical application of PQQ in the prevention and treatment of
liver fibrosis.
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