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10.1111/imr.12287 http://scihub22266oqcxt.onion/10.1111/imr.12287 C4400865!4400865!25879289     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25879289.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Immunol+Rev 2015 ; 265 (1): 130-42 Nephropedia Template TP {{tp|p=25879289|t=2015. Pyroptotic cell death defends against intracellular pathogens |pdf=|usr=}}{{25879289}} gab.com Text Pyroptotic cell death defends against intracellular pathogens JO: Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25879289 #FOAvip Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase-1 induces the activation and secretion of the two prominent pro-inflammatory cytokines, interleukin-1? (IL-1?) and IL-18. Second, either caspase-1 or caspase-11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans. Twit Text FOAVip Pyroptotic cell death defends against intracellular pathogens ????Immunol Rev http://www.kidney.de/pget.php?&tw=1&pmid=25879289 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25879289 #FOAvip English Wikipedia <ref>{{Cite pmid|25879289}}</ref> Pyroptotic cell death defends against intracellular pathogens #MMPMID25879289 Jorgensen I; Miao EA Immunol Rev 2015[May]; 265 (1): 130-42 PMID25879289show ga Inflammatory caspases play a central role in innate immunity by responding to cytosolic signals and initiating a twofold response. First, caspase-1 induces the activation and secretion of the two prominent pro-inflammatory cytokines, interleukin-1? (IL-1?) and IL-18. Second, either caspase-1 or caspase-11 can trigger a form of lytic, programmed cell death called pyroptosis. Pyroptosis operates to remove the replication niche of intracellular pathogens, making them susceptible to phagocytosis and killing by a secondary phagocyte. However, aberrant, systemic activation of pyroptosis in vivo may contribute to sepsis. Emphasizing the efficiency of inflammasome detection of microbial infections, many pathogens have evolved to avoid or subvert pyroptosis. This review focuses on molecular and morphological characteristics of pyroptosis and the individual inflammasomes and their contribution to defense against infection in mice and humans. äPyroptotic cell death defends against intracellular pathogens (epmc).pdf DeepDyve Pubget Overpricing