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2014 ; 2014
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Pyelonephritis (acute) in non-pregnant women
#MMPMID25373019
Neumann I
; Moore P
BMJ Clin Evid
2014[Nov]; 2014
(ä): ä PMID25373019
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INTRODUCTION: Pyelonephritis is usually caused by ascent of bacteria (most often
Escherichia coli) from the bladder, and is more likely in people with structural
or functional urinary tract abnormalities. The prognosis is good if
pyelonephritis is treated appropriately, but complications include renal abscess,
renal impairment, and septic shock. METHODS AND OUTCOMES: We conducted a
systematic review and aimed to answer the following clinical question: What are
the effects of antibiotic treatments for acute pyelonephritis in non-pregnant
women with uncomplicated infection? We searched: Medline, Embase, The Cochrane
Library, and other important databases up to November 2013 (Clinical Evidence
reviews are updated periodically; please check our website for the most
up-to-date version of this review). We included harms alerts from relevant
organisations such as the US Food and Drug Administration (FDA) and the UK
Medicines and Healthcare products Regulatory Agency (MHRA). RESULTS: We found
four studies that met our inclusion criteria. CONCLUSIONS: In this systematic
review we present information relating to the effectiveness and safety of the
following interventions: antibiotics (intravenous), antibiotics (oral), and
antibiotics (switch therapy).
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