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10.3389/fimmu.2018.00399 http://scihub22266oqcxt.onion/10.3389/fimmu.2018.00399 C5837999!5837999 !29545806     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\29545806 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Front+Immunol 2018 ; 9 (ä): 399 Nephropedia Template TP {{tp|p=29545806 |t=2018. Purinergic Regulation of Neutrophil Function |pdf=|usr=}}{{29545806 }} gab.com Text Purinergic Regulation of Neutrophil Function JO: Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29545806 #FOAvip Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through activation of P2 receptors, whereas adenosine mostly functions as an anti-inflammatory molecule through activation of P1 receptors. Neutrophils are the most abundant immune cells in circulation and have emerged as an important component in orchestrating a complex series of events during inflammation. However, because of the destructive nature of neutrophil-derived inflammatory agents, neutrophil activation is fine-tuned, and purinergic signaling is intimately involved in this process. Indeed, shifting the balance between P2 and P1 signaling is critical for neutrophils to appropriately exert their immunologic activity. Here, we review the role of purinergic signaling in regulating neutrophil function, and discuss the potential of targeting purinergic signaling for the treatment of neutrophil-associated infectious and inflammatory diseases. Twit Text FOAVip Purinergic Regulation of Neutrophil Function ????Front Immunol http://www.kidney.de/pget.php?&tw=1&pmid=29545806 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=29545806 #FOAvip English Wikipedia <ref>{{Cite pmid|29545806 }}</ref> Purinergic Regulation of Neutrophil Function #MMPMID29545806 Wang X ; Chen D Front Immunol 2018[]; 9 (ä): 399 PMID29545806 show ga Purinergic signaling, which utilizes nucleotides (particularly ATP) and adenosine as transmitter molecules, plays an essential role in immune system. In the extracellular compartment, ATP predominantly functions as a pro-inflammatory molecule through activation of P2 receptors, whereas adenosine mostly functions as an anti-inflammatory molecule through activation of P1 receptors. Neutrophils are the most abundant immune cells in circulation and have emerged as an important component in orchestrating a complex series of events during inflammation. However, because of the destructive nature of neutrophil-derived inflammatory agents, neutrophil activation is fine-tuned, and purinergic signaling is intimately involved in this process. Indeed, shifting the balance between P2 and P1 signaling is critical for neutrophils to appropriately exert their immunologic activity. Here, we review the role of purinergic signaling in regulating neutrophil function, and discuss the potential of targeting purinergic signaling for the treatment of neutrophil-associated infectious and inflammatory diseases. |*Neutrophil Activation [MESH] |Adenosine Triphosphate/metabolism [MESH] |Adenosine/metabolism [MESH] |Animals [MESH] |Homeostasis [MESH] |Humans [MESH] |Immunomodulation [MESH] |Inflammation Mediators/metabolism [MESH] |Neutrophils/*physiology [MESH] |Purinergic Agents/*immunology [MESH] |Receptors, Purinergic P2/*metabolism [MESH]Purinergic Regulation of Neutrophil Function (epmc).pdf DeepDyve Pubget Overpricing