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10.1016/j.cub.2014.07.076 http://scihub22266oqcxt.onion/10.1016/j.cub.2014.07.076 C4203654!4203654 !25220054     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=25220054 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\25220054 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Curr+Biol 2014 ; 24 (18 ): 2189-2194 Nephropedia Template TP {{tp|p=25220054 |t=2014. Pulsatile dynamics in the yeast proteome |pdf=|usr=}}{{25220054 }} gab.com Text Pulsatile dynamics in the yeast proteome JO: Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=25220054 #FOAvip The activation of transcription factors in response to environmental conditions is fundamental to cellular regulation. Recent work has revealed that some transcription factors are activated in stochastic pulses of nuclear localization, rather than at a constant level, even in a constant environment [1-12]. In such cases, signals control the mean activity of the transcription factor by modulating the frequency, duration, or amplitude of these pulses. Although specific pulsatile transcription factors have been identified in diverse cell types, it has remained unclear how prevalent pulsing is within the cell, how variable pulsing behaviors are between genes, and whether pulsing is specific to transcriptional regulators or is employed more broadly. To address these issues, we performed a proteome-wide movie-based screen to systematically identify localization-based pulsing behaviors in Saccharomyces cerevisiae. The screen examined all genes in a previously developed fluorescent protein fusion library of 4,159 strains [13] in multiple media conditions. This approach revealed stochastic pulsing in ten proteins, all transcription factors. In each case, pulse dynamics were heterogeneous and unsynchronized among cells in clonal populations. Pulsing is the only dynamic localization behavior that we observed, and it tends to occur in pairs of paralogous and redundant proteins. Taken together, these results suggest that pulsatile dynamics play a pervasive role in yeast and may be similarly prevalent in other eukaryotic species. Twit Text FOAVip Pulsatile dynamics in the yeast proteome ????Curr Biol http://www.kidney.de/pget.php?&tw=1&pmid=25220054 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=25220054 #FOAvip English Wikipedia <ref>{{Cite pmid|25220054 }}</ref> Pulsatile dynamics in the yeast proteome #MMPMID25220054 Dalal CK ; Cai L ; Lin Y ; Rahbar K ; Elowitz MB Curr Biol 2014[Sep]; 24 (18 ): 2189-2194 PMID25220054 show ga The activation of transcription factors in response to environmental conditions is fundamental to cellular regulation. Recent work has revealed that some transcription factors are activated in stochastic pulses of nuclear localization, rather than at a constant level, even in a constant environment [1-12]. In such cases, signals control the mean activity of the transcription factor by modulating the frequency, duration, or amplitude of these pulses. Although specific pulsatile transcription factors have been identified in diverse cell types, it has remained unclear how prevalent pulsing is within the cell, how variable pulsing behaviors are between genes, and whether pulsing is specific to transcriptional regulators or is employed more broadly. To address these issues, we performed a proteome-wide movie-based screen to systematically identify localization-based pulsing behaviors in Saccharomyces cerevisiae. The screen examined all genes in a previously developed fluorescent protein fusion library of 4,159 strains [13] in multiple media conditions. This approach revealed stochastic pulsing in ten proteins, all transcription factors. In each case, pulse dynamics were heterogeneous and unsynchronized among cells in clonal populations. Pulsing is the only dynamic localization behavior that we observed, and it tends to occur in pairs of paralogous and redundant proteins. Taken together, these results suggest that pulsatile dynamics play a pervasive role in yeast and may be similarly prevalent in other eukaryotic species. |*Gene Expression Regulation [MESH] |*Proteome [MESH] |Cell Physiological Phenomena [MESH] |Saccharomyces cerevisiae Proteins/*genetics/metabolism [MESH] |Saccharomyces cerevisiae/*genetics/metabolism [MESH]Pulsatile dynamics in the yeast proteome (epmc).pdf DeepDyve Pubget Overpricing