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2013 ; 37
(2
): 124-31
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Pulmonary hypertension in bronchopulmonary dysplasia
#MMPMID23582967
Berkelhamer SK
; Mestan KK
; Steinhorn RH
Semin Perinatol
2013[Apr]; 37
(2
): 124-31
PMID23582967
show ga
Pulmonary hypertension (PH) is a common complication of neonatal respiratory
diseases, including bronchopulmonary dysplasia (BPD), and recent studies have
increased awareness that PH worsens the clinical course, morbidity and mortality
of BPD. Recent evidence indicates that up to 18% of all extremely
low-birth-weight infants will develop some degree of PH during their
hospitalization, and the incidence rises to 25-40% of the infants with
established BPD. Risk factors are not yet well understood, but new evidence shows
that fetal growth restriction is a significant predictor of PH. Echocardiography
remains the primary method for evaluation of BPD-associated PH, and the
development of standardized screening timelines and techniques for identification
of infants with BPD-associated PH remains an important ongoing topic of
investigation. The use of pulmonary vasodilator medications, such as nitric
oxide, sildenafil, and others, in the BPD population is steadily growing, but
additional studies are needed regarding their long-term safety and efficacy.
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