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10.1164/rccm.201503-0609OC http://scihub22266oqcxt.onion/10.1164/rccm.201503-0609OC C4731621!4731621 !26214119     free     free     free Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 227.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26214119 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Respir+Crit+Care+Med 2015 ; 192 (10 ): 1191-9 Nephropedia Template TP {{tp|p=26214119 |t=2015. Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning |pdf=|usr=}}{{26214119 }} gab.com Text Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning JO: Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=26214119 #FOAvip RATIONALE: Carbon monoxide (CO) exposure is a leading cause of poison-related mortality. CO binds to Hb, forming carboxyhemoglobin (COHb), and produces tissue damage. Treatment of CO poisoning requires rapid removal of CO and restoration of oxygen delivery. Visible light is known to effectively dissociate CO from Hb, with a single photon dissociating one CO molecule. OBJECTIVES: To determine whether illumination of the lungs of CO-poisoned mice causes dissociation of COHb from blood transiting the lungs, releasing CO into alveoli and thereby enhancing the rate of CO elimination. METHODS: We developed a model of CO poisoning in anesthetized and mechanically ventilated mice to assess the effects of direct lung illumination (phototherapy) on the CO elimination rate. Light at wavelengths between 532 and 690 nm was tested. The effect of lung phototherapy administered during CO poisoning was also studied. To avoid a thoracotomy, we assessed the effect of lung phototherapy delivered to murine lungs via an optical fiber placed in the esophagus. MEASUREMENTS AND MAIN RESULTS: In CO-poisoned mice, phototherapy of exposed lungs at 532, 570, 592, and 628 nm dissociated CO from Hb and doubled the CO elimination rate. Phototherapy administered during severe CO poisoning limited the blood COHb increase and improved the survival rate. Noninvasive transesophageal phototherapy delivered to murine lungs via an optical fiber increased the rate of CO elimination while avoiding a thoracotomy. CONCLUSIONS: Future development and scaling up of lung phototherapy for patients with CO exposure may provide a significant advance for treating and preventing CO poisoning. Twit Text FOAVip Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning ????Am J Respir Crit Care Med http://www.kidney.de/pget.php?&tw=1&pmid=26214119 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26214119 #FOAvip English Wikipedia <ref>{{Cite pmid|26214119 }}</ref> Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning #MMPMID26214119 Zazzeron L ; Liu C ; Franco W ; Nakagawa A ; Farinelli WA ; Bloch DB ; Anderson RR ; Zapol WM Am J Respir Crit Care Med 2015[Nov]; 192 (10 ): 1191-9 PMID26214119 show ga RATIONALE: Carbon monoxide (CO) exposure is a leading cause of poison-related mortality. CO binds to Hb, forming carboxyhemoglobin (COHb), and produces tissue damage. Treatment of CO poisoning requires rapid removal of CO and restoration of oxygen delivery. Visible light is known to effectively dissociate CO from Hb, with a single photon dissociating one CO molecule. OBJECTIVES: To determine whether illumination of the lungs of CO-poisoned mice causes dissociation of COHb from blood transiting the lungs, releasing CO into alveoli and thereby enhancing the rate of CO elimination. METHODS: We developed a model of CO poisoning in anesthetized and mechanically ventilated mice to assess the effects of direct lung illumination (phototherapy) on the CO elimination rate. Light at wavelengths between 532 and 690 nm was tested. The effect of lung phototherapy administered during CO poisoning was also studied. To avoid a thoracotomy, we assessed the effect of lung phototherapy delivered to murine lungs via an optical fiber placed in the esophagus. MEASUREMENTS AND MAIN RESULTS: In CO-poisoned mice, phototherapy of exposed lungs at 532, 570, 592, and 628 nm dissociated CO from Hb and doubled the CO elimination rate. Phototherapy administered during severe CO poisoning limited the blood COHb increase and improved the survival rate. Noninvasive transesophageal phototherapy delivered to murine lungs via an optical fiber increased the rate of CO elimination while avoiding a thoracotomy. CONCLUSIONS: Future development and scaling up of lung phototherapy for patients with CO exposure may provide a significant advance for treating and preventing CO poisoning. |Animals [MESH] |Carbon Monoxide Poisoning/blood/*therapy [MESH] |Carboxyhemoglobin/analysis/*metabolism [MESH] |Disease Models, Animal [MESH] |Metabolic Clearance Rate/physiology [MESH] |Mice [MESH]Pulmonary Phototherapy for Treating Carbon Monoxide Poisoning (epmc).pdf DeepDyve Pubget Overpricing