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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Clin+Chest+Med
2016 ; 37
(3
): 441-8
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Pulmonary Alveolar Microlithiasis
#MMPMID27514591
Saito A
; McCormack FX
Clin Chest Med
2016[Sep]; 37
(3
): 441-8
PMID27514591
show ga
Pulmonary alveolar microlithiasis (PAM) is a genetic lung disorder that is
characterized by the accumulation of calcium phosphate deposits in the alveolar
spaces of the lung. Mutations in the type II sodium phosphate cotransporter,
NPT2b, have been reported in patients with PAM. PAM progresses gradually, often
producing incremental dyspnea on exertion, desaturation in young adulthood, and
respiratory insufficiency by late middle age. Treatment remains supportive,
including supplemental oxygen therapy. For patients with end-stage disease, lung
transplantation is available as a last resort. The recent development of a
laboratory animal model has revealed several promising treatment approaches for
future trials.
|*Lung Transplantation
[MESH]
|*Oxygen Inhalation Therapy
[MESH]
|Bone Density Conservation Agents/*therapeutic use
[MESH]
free
free
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