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2018 ; 15
(4
): 3551-3555
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Pterostilbene attenuates acute kidney injury in septic mice
#MMPMID29545882
Xia Y
; Chen Y
; Tang L
; Wang Z
; Zheng Y
Exp Ther Med
2018[Apr]; 15
(4
): 3551-3555
PMID29545882
show ga
Acute kidney injury (AKI) is a severe complication of sepsis with a high
mortality and morbidity. Pterostilbene (Pte) has been suggested to confer
anti-apoptotic and anti-inflammatory effects. In the current study, the effects
of Pte on AKI were evaluated in septic mice. Cecal ligation and puncture surgery
was performed to induce sepsis. The results suggested that Pte administration
significantly decreased the levels of serum urea nitrogen and creatinine, and
improved the survival rate of septic mice. Additionally, the renal injury induced
by sepsis was attenuated by pterostilbene treatment. Notably, pterostilbene
reduced Bcl-2-associated X protein expression, and levels of interleukin-1? and
tumor necrosis factor-?, and upregulated B-cell lymphoma 2 expression. The
results indicate that pterostilbene may serve as a potential therapeutic
candidate for the treatment of AKI induced by sepsis.