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2016 ; 7
(ä): 348
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Psychopaths Show Enhanced Amygdala Activation during Fear Conditioning
#MMPMID27014154
Front Psychol
2016[]; 7
(ä): 348
PMID27014154
show ga
Psychopathy is a personality disorder characterized by emotional deficits and a
failure to inhibit impulsive behavior and is often subdivided into "primary" and
"secondary" psychopathic subtypes. The maladaptive behavior related to primary
psychopathy is thought to reflect constitutional "fearlessness," while the
problematic behavior related to secondary psychopathy is motivated by other
factors. The fearlessness observed in psychopathy has often been interpreted as
reflecting a fundamental deficit in amygdala function, and previous studies have
provided support for a low-fear model of psychopathy. However, many of these
studies fail to use appropriate screening procedures, use liberal inclusion
criteria, or have used unconventional approaches to assay amygdala function. We
measured brain activity with BOLD imaging in primary and secondary psychopaths
and non-psychopathic control subjects during Pavlovian fear conditioning. In
contrast to the low-fear model, we observed normal fear expression in primary
psychopaths. Psychopaths also displayed greater differential BOLD activity in the
amygdala relative to matched controls. Inverse patterns of activity were observed
in the anterior cingulate cortex (ACC) for primary versus secondary psychopaths.
Primary psychopaths exhibited a pattern of activity in the dorsal and ventral ACC
consistent with enhanced fear expression, while secondary psychopaths exhibited a
pattern of activity in these regions consistent with fear inhibition. These
results contradict the low-fear model of psychopathy and suggest that the low
fear observed for psychopaths in previous studies may be specific to secondary
psychopaths.