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2018 ; 2018
(ä): 9625936
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Pruritus: Progress toward Pathogenesis and Treatment
#MMPMID29850592
Song J
; Xian D
; Yang L
; Xiong X
; Lai R
; Zhong J
Biomed Res Int
2018[]; 2018
(ä): 9625936
PMID29850592
show ga
Pruritus, the most common cutaneous symptom, is widely seen in many skin
complaints. It is an uncomfortable feeling on the skin and sometimes impairs
patients' quality of life. At present, the specific mechanism of pruritus still
remains unclear. Antihistamines, which are usually used to relieve pruritus,
ineffectively work in some patients with itching. Recent evidence has suggested
that, apart from histamine, many mediators and signaling pathways are involved in
the pathogenesis of pruritus. Various therapeutic options for itching
correspondingly have been developed. In this review, we summarize the updated
pathogenesis and therapeutic strategies for pruritus.