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2017 ; 60-61
(ä): 38-56
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Provisional matrix: A role for versican and hyaluronan
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Wight TN
Matrix Biol
2017[Jul]; 60-61
(ä): 38-56
PMID27932299
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Hyaluronan and versican are extracellular matrix (ECM) components that are
enriched in the provisional matrices that form during the early stages of
development and disease. These two molecules interact to create pericellular
"coats" and "open space" that facilitate cell sorting, proliferation, migration,
and survival. Such complexes also impact the recruitment of leukocytes during
development and in the early stages of disease. Once thought to be inert
components of the ECM that help hold cells together, it is now quite clear that
they play important roles in controlling cell phenotype, shaping tissue response
to injury and maintaining tissue homeostasis. Conversion of
hyaluronan-/versican-enriched provisional matrix to collagen-rich matrix is a
"hallmark" of tissue fibrosis. Targeting the hyaluronan and versican content of
provisional matrices in a variety of diseases including, cardiovascular disease
and cancer, is becoming an attractive strategy for intervention.
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