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2015 ; 161
(1
): 23-30
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Proteomics and autoimmune kidney disease
#MMPMID25979820
Rovin BH
; Klein JB
Clin Immunol
2015[Nov]; 161
(1
): 23-30
PMID25979820
show ga
Proteomics has long been considered an ideal platform, and urine an ideal source
for biomarker discovery in human autoimmune kidney diseases. A number of studies
have examined the urine proteome to identify biomarkers of disease activity,
kidney pathology, and response to therapy. Increasingly, proteomic studies of
kidney disease have expanded to include blood, circulating cells and kidney
tissue. Recently the clinical potential of renal proteomics has been realized
through a handful of investigations whose results appear to be applicable to
patient care. In this review, approaches to the proteomic evaluation of
autoimmune kidney diseases will be considered in the context of developing
clinically useful disease biomarkers.
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