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10.1016/j.tibs.2017.02.006

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suck abstract from ncbi


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pmid28284537
      Trends+Biochem+Sci 2017 ; 42 (5 ): 342-354
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  • Proteome-Scale Human Interactomics #MMPMID28284537
  • Luck K ; Sheynkman GM ; Zhang I ; Vidal M
  • Trends Biochem Sci 2017[May]; 42 (5 ): 342-354 PMID28284537 show ga
  • Cellular functions are mediated by complex interactome networks of physical, biochemical, and functional interactions between DNA sequences, RNA molecules, proteins, lipids, and small metabolites. A thorough understanding of cellular organization requires accurate and relatively complete models of interactome networks at proteome scale. The recent publication of four human protein-protein interaction (PPI) maps represents a technological breakthrough and an unprecedented resource for the scientific community, heralding a new era of proteome-scale human interactomics. Our knowledge gained from these and complementary studies provides fresh insights into the opportunities and challenges when analyzing systematically generated interactome data, defines a clear roadmap towards the generation of a first reference interactome, and reveals new perspectives on the organization of cellular life.
  • |*Protein Interaction Mapping [MESH]
  • |*Protein Interaction Maps [MESH]
  • |Humans [MESH]
  • |Protein Binding [MESH]
  • |Proteins/chemistry/*metabolism [MESH]
  • |Proteome/*metabolism [MESH]


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