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2017 ; 42
(5
): 342-354
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Proteome-Scale Human Interactomics
#MMPMID28284537
Luck K
; Sheynkman GM
; Zhang I
; Vidal M
Trends Biochem Sci
2017[May]; 42
(5
): 342-354
PMID28284537
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Cellular functions are mediated by complex interactome networks of physical,
biochemical, and functional interactions between DNA sequences, RNA molecules,
proteins, lipids, and small metabolites. A thorough understanding of cellular
organization requires accurate and relatively complete models of interactome
networks at proteome scale. The recent publication of four human protein-protein
interaction (PPI) maps represents a technological breakthrough and an
unprecedented resource for the scientific community, heralding a new era of
proteome-scale human interactomics. Our knowledge gained from these and
complementary studies provides fresh insights into the opportunities and
challenges when analyzing systematically generated interactome data, defines a
clear roadmap towards the generation of a first reference interactome, and
reveals new perspectives on the organization of cellular life.