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2018 ; 2
(2
): 240-250
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Proteolytic processing of platelet receptors
#MMPMID30046726
Gardiner EE
Res Pract Thromb Haemost
2018[Apr]; 2
(2
): 240-250
PMID30046726
show ga
Platelets have a major role in hemostasis and an emerging role in biological
processes including inflammation and immunity. Many of these processes require
platelet adhesion and localization at sites of tissue damage or infection and
regulated platelet activation, mediated by platelet adheso-signalling receptors,
glycoprotein (GP) Ib-IX-V and GPVI. Work from a number of laboratories has
demonstrated that levels of these receptors are closely regulated by
metalloproteinases of the A Disintegrin And Metalloproteinase (ADAM) family,
primarily ADAM17 and ADAM10. It is becoming increasingly evident that platelets
have important roles in innate immunity, inflammation, and in combating infection
that extends beyond processes of hemostasis. This overview will examine the
molecular events that regulate levels of platelet receptors and then assess
ramifications for these events in settings where hemostasis, inflammation, and
infection processes are triggered.