Use my Search Websuite to scan PubMed, PMCentral, Journal Hosts and Journal Archives, FullText. Kick-your-searchterm to multiple Engines kick-your-query now !>

A dictionary by aggregated review articles of nephrology, medicine and the life sciences Your one-stop-run pathway from word to the immediate pdf of peer-reviewed on-topic knowledge.

10.1038/ncomms10241 http://scihub22266oqcxt.onion/10.1038/ncomms10241 C4729864!4729864 !26742890     free     free     free Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\26742890 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Nat+Commun 2016 ; 7 (ä): 10241 Nephropedia Template TP {{tp|p=26742890 |t=2016. Protein-targeted corona phase molecular recognition |pdf=|usr=}}{{26742890 }} gab.com Text Protein-targeted corona phase molecular recognition JO: Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26742890 #FOAvip Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated by the quenching kinetics. The fibrinogen recognition also occurs in serum environment, at the clinically relevant fibrinogen concentrations in the human blood. These results open new avenues for synthetic, non-biological antibody analogues that recognize biological macromolecules, and hold great promise for medical and clinical applications. Twit Text FOAVip Protein-targeted corona phase molecular recognition ????Nat Commun http://www.kidney.de/pget.php?&tw=1&pmid=26742890 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=26742890 #FOAvip English Wikipedia <ref>{{Cite pmid|26742890 }}</ref> Protein-targeted corona phase molecular recognition #MMPMID26742890 Bisker G ; Dong J ; Park HD ; Iverson NM ; Ahn J ; Nelson JT ; Landry MP ; Kruss S ; Strano MS Nat Commun 2016[Jan]; 7 (ä): 10241 PMID26742890 show ga Corona phase molecular recognition (CoPhMoRe) uses a heteropolymer adsorbed onto and templated by a nanoparticle surface to recognize a specific target analyte. This method has not yet been extended to macromolecular analytes, including proteins. Herein we develop a variant of a CoPhMoRe screening procedure of single-walled carbon nanotubes (SWCNT) and use it against a panel of human blood proteins, revealing a specific corona phase that recognizes fibrinogen with high selectivity. In response to fibrinogen binding, SWCNT fluorescence decreases by >80% at saturation. Sequential binding of the three fibrinogen nodules is suggested by selective fluorescence quenching by isolated sub-domains and validated by the quenching kinetics. The fibrinogen recognition also occurs in serum environment, at the clinically relevant fibrinogen concentrations in the human blood. These results open new avenues for synthetic, non-biological antibody analogues that recognize biological macromolecules, and hold great promise for medical and clinical applications. |*Nanotubes, Carbon [MESH] |*Polymers [MESH] |*Protein Corona [MESH] |Blood Proteins/chemistry [MESH] |Fibrinogen/*chemistry [MESH] |Fluorescence [MESH] |High-Throughput Screening Assays/*methods [MESH]Protein-targeted corona phase molecular recognition (epmc).pdf DeepDyve Pubget Overpricing